Craig B. Fryhle

Professor

Department of Chemistry
Pacific Lutheran University
Tacoma, WA 98447

253-535-8314 (office)
fryhle@chem.plu.edu

Ph.D., Brown University, Providence, Rhode Island, 1985, Organic Chemistry

B.A., Gettysburg College, Gettysburg, Pennsylvania, 1979, Chemistry
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Chemical Education Initiatives

Coauthor with T. W. Graham Solomons of Organic Chemistry, 7th Edition (John Wiley and Sons, Inc.). Contributions to Fundamentals of Organic Chemistry, 5th Edition. (John Wiley and Sons, Inc.), and the accompanying Study Guides.

The FTNMR Archive is a collection of nuclear magnetic resonance spectral data for small organic molecules. The archive is maintained and located at Pacific Lutheran University. The FTNMR Archive contains 300 MHz proton and 75 MHz 13C NMR spectra run on the broad band FTNMR spectrometer at Pacific Lutheran University. Files are provided in FID (free induction decay, i.e. unprocessed data) format so as to allow local processing. A special section of the archive is devoted to the NMR spectra used in the Sixth and Seventh editions of Organic Chemistry . Please follow the above links for more information.

CIRRUS is a WWW site with a variety of information and links pertinent to undergraduate research in chemistry. The site is maintained and located at Pacific Lutheran University. CIRRUS includes information about ACS Student Affiliate Undergraduate Research Symposia, abstracts for research presentations by undergraduates, a listing of summer research opportunities available around the United States, links to graduate schools, other Chemistry Departments, the Council for Undergraduate Research, the Journal of Chemical Education, career, scholarship and fellowship information, and links to Internet chemistry research sites such as CAS On-line, the American Chemical Society Home Page, and the National Institutes of Health Home Page. Please follow this link to CIRRUS for more information on undergraduate research.

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Research Areas

 The mechanism and structure of 5-amino-3-hydroxybenzoic acid (AHBA) synthase, a 93 kD enzyme of the shikimic acid metabolic pathway in microorganisms, has been probed by synthesis of purported reaction intermediates, isotopic labeling, and electrospray ionization mass spectroscopy (ESI MS). At present, sequence homology and molecular modeling studies are being conducted using a Silicon Graphics Indigo2 Power Extreme workstation. Three students have been involved in this project to date.

 Undergraduate research students at Pacific Lutheran University have prepared synthetic intermediates in a scheme for the total synthesis of an inhibitor of chorismate synthase, an enzyme in the shikimate pathway. The inhibitor may help elucidate the mechanism of chorismate synthase and could have potential use as an herbicide or bactericide. Synthetic work has utilized standard laboratory methods of organic chemistry, as well as 300 MHz one- and two- dimensional multinuclear FTNMR, GCMS and FTIR spectrometry. Conformational properties of shikimic acid and analogues are also being studied by NMR and molecular modeling techniques. Seven students have been involved in this project to date.

 New experiments have been developed for the undergraduate organic and instrumental analysis laboratories. Reaction mechanisms, methods of compound purification, principles of spectroscopic analysis and the use of modern instrumentation have been illustrated by these experiments.

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Information Relevant to Courses Taught by Me

  • Organic Chemistry Lecture I

    • (Chem 232)
     
     
  • Organic Chemistry Laboratory I

    • (Chem 234)
  • Organic Chemistry Lecture II

    • (Chem 332)
     
     
  • Organic Chemistry Laboratory II

    • (Chem 334)
  • Organic Special Projects Laboratory 

    • (Chem 336)
  • Advanced Organic Chemistry 

    • (Chem 440)
  • Instrumental Analysis

    • (Chem 435)
    (under most conditions)
  • Introduction to Research 

    • (Chem 410)
  • Chemistry Seminar

    • (Chem 490)

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    Tool Kit for Organic Chemistry

    Link Comments
    Rasmol  Viewer for structures in .PDB format 
    (U.C. Berkeley Version)
    Molecular Models Intro Page  PDB Structure Files for Small Organic Molecules 
    (Okanagon University College)
    ISIS/Draw A Chemical Drawing Program
    Chime A Rasmol Plugin for Netscape
    Molecular Design Limited Homepage Suppliers of ISIS/Draw and Chime
    Organic Chemistry Resources Worldwide Links to Many Other Sites 
    Chemistry Hypermedia Project  Virginia Tech.

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    Other WWW Links

    Links of Personal Interest

    Here are some links to Climbing Resources on the Web.
    Here is a list with links to photos of a few favorite mountains.
    Here are links to a few family photos.

    Contact Information

    Please feel free to contact me by email, regular mail, or telephone.

    Craig B. Fryhle, Ph.D.
    Professor of Chemistry and Chairperson
    Department of Chemistry
    Pacific Lutheran University
    Tacoma, Washington 98447
    253-535-8314 (office)
    253-536-5055 (fax)
     

    fryhle@chem.plu.edu

     

     

     Follow this link to the Department of Chemistry's Home Page

    Last Modified December 2000
    Copyright, Craig B. Fryhle