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Seminar - Bioorganic Chemistry at the Palouse: Peptide-based Sensors of Lipid Nanovesicle BiomarkersJonel SaludesWashington State UniversityBioorganic Chemistry at the Palouse: Peptide-based Sensorsof Lipid Nanovesicle BiomarkersMonday, Oct. 2912:30 pmMorken 137Dr. Saludes's research interests focus on developing peptides to deliver bioactive molecules across membrane bilayers. He utilizes tools from organic chemistry, spectroscopy and bioanalytics to address his research questions. If you would like more information about Jonel at his WSU profile page (http://organic.wsu.edu/faculty/saludes). An announcement is also posted at our Seminar web page.
Seminar, September 28: Professor Karla Satchell (PLU '88), Feinberg School of Medicine, Northwestern University
Biochemical mechanisms of protein toxin action and their contribution to progression of bacterial infection
Friday, September 28, 2012
3:00 p.m. Morken 103
Refreshments and conversation at 2:40
Professor Karla Satchell (PLU '88)
Associate Professor of Microbiology-Immunology
Feinberg School of Medicine
Print and post a flyer.
Summary: Bacterial - host interactions frequently involve mechanisms for translocation of “effector” proteins from bacteria into eukaryotic cells. Within the host cell, these effectors modulate cell biological processes resulting in cytopathic and sometime cytotoxic effects that ultimately benefit the infectious agent. The Satchell lab studies toxins that deliver numerous effectors to cells; these are known as the Multifunctional-Autoprocessing RTX (MARTX) toxins. The toxins themselves are very large single polypeptides (ranging from 3500-5200 aa) that are secreted from bacteria. The central portion of the toxins are subsequently transferred into eukaryotic cells where the toxin is activated by binding a small molecule that initiates the toxin to process itself. The released protein fragments are effectors that are then free in the cytosol to access cellular targets to initiate cytopathic and cytotoxic effects. A notable feature distinguishing MARTX toxins of different species is that the effector repertoire can vary with a single toxin carrying anywhere from 1 to 5 effectors. Dr. Satchell will present data demonstrating how autoprocessing leads to delivery of effectors and how distinct toxins with different effector combinations can lead to dramatically different disease outcomes after intestinal infection, from diarrhea to septicemia and necrotizing fasciitis.
Biography: Dr. Karla Satchell (nee Fullner) graduated from PLU with a B.S. in Biology and minor in Chemistry in 1988. After graduating, she worked as a technician at the University of Washington Department of Pharmacology for 2 years gaining valuable research experience and starting what would become a life long interest in bacterial toxins. She entered the graduate program in Microbiology at the University of Washington and completed a Ph.D. studying how the bacterium Agrobacterium tumefaciens transfers DNA to plant cells. Her graduate work was published in the journal Science. She then studied at the University of Pittsburgh examining bacteriophages of Mycobacterium and how these phages infect the bacterium responsible for tuberculosis. In 1997, she moved to Harvard Medical School in Boston to conduct research on the bacterium Vibrio cholerae. As part of this work, she returned to her original interest in bacterial toxins, ultimately discovering and characterizing a new family of toxins known as the MARTX toxins. She joined the faculty at Northwestern University Feinberg School of Medicine in Chicago in 2000 and has built a vigorous research program focused on toxins and how these toxins contribute to progression of bacterial infections. Her work centers on two bacteria: Vibrio cholerae and how toxins contribute to cholera disease and Vibrio vulnificus, a seafood-bourne pathogen that causes severe septicemia and necrotizing fasciitis. Dr. Satchell’s research is highly interdisciplinary crossing the fields of microbiology, immunology, cell biology, biochemistry, and structural biology. Her current research group has eight scientists and funding from the National Institutes of Health and private foundations. She has published nearly 50 research articles. In addition, Dr. Satchell is the proud mother of 7 year old son Grant and serves as a consultant to Situ Biosciences, a start-up biotech company founded by her husband.
Attachment Size Karla (Fullner) Satchell PLU Seminar Flyer.pdf 44.53 KB
REACH (Registration, Evaluation, Authorization and Restriction of Chemical substances)
Martin Schneiter, PLU MBA
Sustainability Director at Huntsman Chemicals
Tuesday Sept. 11, Noon
How Subversion, Revolution, and Climate Change Lead to Innovative Science--Enhancing Electrochemical Energy Storage
How Subversion, Revolution, and Climate Change Lead to Innovative Science--Enhancing Electrochemical Energy Storage on the Macroscale via Architectural Design on the Nanoscale
Dr. Debra Rolison
Head, Advanced Electrochemical Materials Section
Naval Research Laboratory
Friday, September 7th
Morken Center for Learning and Technology 103
On September 7th, 2012, the PLU Chemistry Department will host a seminar by Dr. Debra Rolison in Morken 103 from 12:30-1:35 PM. In her presentation, “How Subversion, Revolution, and Climate Change Lead to Innovative Science--Enhancing Electrochemical Energy Storage on the Macroscale via Architectural Design on the Nanoscale,” Dr. Rolison will share her passion for empowering women and minorities in the sciences, and will give an overview of her research with nanomaterials to create better batteries, capacitors, and fuel cells. Here is a link to a flyer.
Dr. Rolison received a B.S. in Chemistry from Florida Atlantic University in 1975 and a Ph.D. in Chemistry from the University of North Carolina at Chapel Hill in 1980 under the direction of Royce W. Murray. She joined the Naval Research Laboratory as a research chemist in 1980 and currently heads NRL’s Advanced Electrochemical Materials section. She is also an Adjunct Full Professor of Chemistry at the University of Utah, and is a Fellow of the American Association for the Advancement of Science (AAAS), the Materials Research Society (MRS) and the American Chemical Society (ACS). She received the ACS Award in Chemistry of Materials in 2011 (and was the first woman to do so) and will be the recipient of the Society for Electroanalytical Chemistry (SEAC) Charles N. Reilley Award in 2012. Rolison’s research at the NRL focuses on multifunctional nanoarchitectures, with emphases on new nanostructured materials for catalytic chemistries, energy storage and conversion, biomolecular composites, porous magnets, and sensors. She is the principal inventor of composite aerogels; electrified microheterogeneous catalysis; a process to electrodesulfurize carbons and coals under mild conditions; and 3-D nanowired mesoporous architectures.
Attachment Size Debra Rolison seminar announcement 090712.pdf 145.22 KB